Category «3_2018»

TROMBOGEMORRAGICAL SYNDROME AS COMPLICATION OF FALCIPARUM MALARIA

V.D. Chernyshev1, A.K. Tokmalayev2, N.A. Polovinkina2, V.B. Chentsov1,G.M. Kozhevnikova2

1 Infectious diseases clinical hospital No2, Moscow

2 Peoples’ Friendship University of Russia, Moscow

Complicating the course of many diseases, including one of the most severe forms of P. falciparum malaria, the thrombohemorrhagical syndrome or a disseminated intravascular syndrome (DIC-syndrome) is the main pathogenetic mechanism, leading to a lethal outcome. Results of observations of patients with the heavy course of tropical malaria are presented in article. All patients under laboratory tests showed signs of disturbances in the system of blood clotting of various degrees, up to typical mani- festations of DIC syndrome, in some cases rapidly progressing against other serious complications of the disease. In the analysis of deaths from autopsy data, two patients were caused by hemorrhages to the vital centers of the brain as a complication of thrombohemorrhagical syndrome.

Key words: tropical malaria, severe forms, thrombohemorrhagical syndrome

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doi: 10.33092/mp2018.3.03-05

PREVALENCE OF INTESTINAL HELMINTHIASES AND PROTOZOOSES AMONG HIV-INFECTED PATIENTS

Yu.A. Tyurin 1,2 , I.D. Reshetnikova1,3, E.V. Agafonova1,2 , E.I. Khayrutdinova4

1 FBUN «Kazan Scientific Research Institute of Epidemiology and Micribiology» of Rospotrebnadzor;

2 FGBOU VO «Kazan State Medical University» of the Ministry of Health of the Russian Federation;2

3 Kazan State Medical University, Ministry of Health of Russia, Kazan, Russia

4 State Autonomic public Health institution «Republicam Center for the Prevention and Control of AIDS and Infec- tion Diseases of the Ministry of Health of the Republic of Tatarstan».

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doi: 10.33092/mp2018.3.25-30

 

ANTHELMINTIC AND TOXICOLOGICAL ASSESSMENT OF SUPRAMOLECULAR TRICLABENDAZOLE COMPLEXES

M.B. Musaev1,  M.V. Milenina1, M.S. Khalikov2, , I.A. Arkhipov1 A.I. Varlamovа1, I.M. Odoevskaya1  , Novik T.S.1

Out of 10 supramolecular triclabendazole complexes with various polymeric excipients (hydroxyethyl starch, polyvinyl pyrrolidone, pharmacopoeian arabinogalactan, technical, sodium carboxymethyl cellulose, silicon dioxide -SiO2, kelp, fucus), on the basis of toxicological and helminthological research and economic prospects for introduction into veterinary practice, a triclabendazole – arabinogalactan (technical grade) complex (triclofascide) was selected. This is an arabinogalactan (technical grade) polysaccharide-based complex of triclabendazole extracted from Siberian larch in the ratio 1:10.

Triclofascide, in contrast to the substance of triclabendazole, is soluble in water, more easy to use and has a high anthelmintic efficiency in a 5 times smaller therapeutic dose. This reduces the cost of animal treatment in comparison to the treatment with triclabendazole substance. The drug has a high biological availability to the parasite. In the animal’s organism the drug dissociates into metabolites and having been excreted in faeces and urine in miniscule amounts.

Triclofascide preclinical toxicology trial showed that in the parameters of acute toxicity, acute cutaneous toxicity at enteral routes of administration to white mice and rats it may be classifie as  IV hazard class. It has no adverse irritating effect on intact skin, and belongs to a group of substances with slightly pronounced cumulative properties. It does not show immunotoxic, embryotoxic and teratogenic activity.

Triclofascide used for treatment of an acute and chronic fascioliasis: for sheep in a therapeutic dose of 2.0 mg/kg individually in the form of an aqueous solution; by group method mixed with food in a therapeutic dose of 3.0 mg/kg; for cattle, respectively, 2.5 and 3.0 mg/kg.

Key words: 10 supramolecular complexes of triclabendazole, тoxicological, helminthological researches

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doi:10.33092/mp2018.3.15-24

FAUNISTIC COMPLEXES OF CAUCASIAN MOUNTAIN GROUND SQUIRREL FLEAS WITHIN THE TERRITORY OF THE CENTRAL CAUCASIAN HIGH-MOUNTAIN NATURAL FOCUS OF PLAGUE

L.I. Belyavtseva1, E.A. Koteneva1, G.A. Mozloev2, N.V. Tsapko1, N.A. Davydova1,V.M. Dubyansky1

1FKUZ Stavropol Antiplague Institute of the Rospotrebnadzor, Stavropol

2FKUZ Kabardino-Balkarian Antiplague Station of the Rospotrebnadzor, Nalchik

The article presents data on distribution of fleas of Caucasian mountain ground squirrel within the territory of the Central Caucasian high-mountain natural focus of plague. To illustrate the difference of faunistic complexes of these paFrasites in all parts of the Caucasian mountain ground squirrel’s geographical range, including high-altitude belts, specific indexes of dominance of flea imago in their hosts’ nests are used. Faunistic complexes of fleas of mountain ground squirrel consist of species capable to exist in climatic conditions of particular parts of the host’s range. Imagoes of the main vector of the plague causative agent, C. t. elbrusensis, dominate within all the territory of the focus; the distribution of the secondary vector (N. s. setosa) and incidental vectors (F. semura, O i. ilovaiskii and R. li) is different and limited by climatic conditions. Key words: Caucasian mountain ground squirrel, fleas, natural focus of plague, carriers, vectors, area, species composition, indexes of dominance.Full text

doi: 10.33092/mp2018.3.05-09

 

EPIDEMIC PRECONDITIONS FOR THE DISTRIBUTION OF DYROFILIAROSIS IN THE CENTRAL BLACK EARTH REGION OF RUSSIA

N.S. Bespalova1, T.A. Zolotikh2

1Voronezh State Agrarian University of The Name Of Emperor Peter I, Voronezh)

2Veterinary clinic VetLiga, Voronezh

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doi: 10.33092/mp2018.3.30-35

 

DIAGNOSIS OF EARLY STAGE OF LARVAL/TISSUE HELMINTHIASES

A.V. Kondrashin1, E.V. Stepanova1, M.S. Maksimova1, N.A. Turbabina1, L.F. Morozova, E.N. Morozov1,2

Parasitoses – helminthiases in general and helminthiases-zoonoses (Echinococcus and other) in particular, are a major threat not only to the health but sometime to the life of affected population both in the developing and industrial countries. The rapid and reliable diagnosis of helminth infections is central to their prevention and control. Effective diagnosis depends on the sensitivity, specificity and reliability of the tests deployed. The most commonly used diagnosis of helminth infection has been the microscopic detection of eggs in fecal samples. Serological methods are also widely used. DNA amplification tests (PCR and its modifications) can provide alternative approach for diagnosis and can be sensitive and specific, provided reliable molecular genetic markers are employed in the tests. Their use can be also useful for quantitative assessment of intensity of infection and in case of mixed helminthiases.  These methods can be deployed under different clinic-epidemiological settings

– various health treatment facilities and in the field, including epidemiological surveys.

    Key words: tissue helminthiasis; diagnostic methods

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doi: 10.33092/mp2018.3.44-50